Editorial


Target RNA-directed microRNA degradation; which controls which?

Mitsuo Kato

Abstract

In general, microRNAs (miRNAs) control target gene expression by inhibiting translation and destroying target RNAs (1,2). However, interestingly some endogenous coding or noncoding RNAs have a function to sequester miRNAs from the real target RNAs by hybridization (called sponge function) without degradation and they are also known as competing endogenous RNAs (ceRNAs) (3,4).

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