A circular RNA regulator quaking: a novel gold mine to be unfolded in doxorubicin-mediated cardiotoxicity

Tatsuya Aonuma, Ahmed S. Bayoumi, Yaoliang Tang, Il-man Kim


The death rate from cancer in the USA has declined steadily over the past 2 decades (1). Improved cancer survival associated with anticancer agents has led to a greater recognition of the late effects of cardiotoxicity including left ventricular dysfunction, heart failure and coronary heart disease.