TY - JOUR AU - La Porta, Caterina A. M. PY - 2019 TI - Impact of circRNA on the complex regulatory network of the cell JF - Non-coding RNA Investigation; Vol 3 (May 2019): Non-coding RNA Investigation Y2 - 2019 KW - N2 - MicroRNAs (miRNAs) are small nucleotides that can bind to messenger RNA (mRNA) preventing its translation. Different mRNA targets can have the same miRNA binding site leading to a miRNA-mediated cross-talk between competitive endogenous RNA (ceRNA) species (1-3). Circular RNAs (circRNAs) are yet another example of ceRNAs (4), first discovered by electron microscopy in an RNA virus in 1976 (5). These are single stranded non-coding RNAs that have their 3' and 5' ends covalently linked due to back-splicing, thus acquiring a circular form. Due to their low transcript abundance, circRNAs were originally thought to be a byproduct of aberrant splicing of mRNA (6). In recent years, however, progress in high-throughput technologies and bioinformatics lead to the identification of many new circRNAs. UR - https://ncri.amegroups.org/article/view/5128