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Impact of circRNA on the complex regulatory network of the cell

	author = {Caterina A. M. La Porta},
	title = {Impact of circRNA on the complex regulatory network of the cell},
	journal = {Non-coding RNA Investigation},
	volume = {3},
	number = {0},
	year = {2019},
	keywords = {},
	abstract = {MicroRNAs (miRNAs) are small nucleotides that can bind to messenger RNA (mRNA) preventing its translation. Different mRNA targets can have the same miRNA binding site leading to a miRNA-mediated cross-talk between competitive endogenous RNA (ceRNA) species (1-3). Circular RNAs (circRNAs) are yet another example of ceRNAs (4), first discovered by electron microscopy in an RNA virus in 1976 (5). These are single stranded non-coding RNAs that have their 3' and 5' ends covalently linked due to back-splicing, thus acquiring a circular form. Due to their low transcript abundance, circRNAs were originally thought to be a byproduct of aberrant splicing of mRNA (6). In recent years, however, progress in high-throughput technologies and bioinformatics lead to the identification of many new circRNAs.},
	url = {}