Therapeutic strategies for targeting non-coding RNAs with special emphasis on novel delivery systems

Rajendra Awasthi, Jyotsana R. Madan, Himaja Malipeddi, Kamal Dua, Giriraj T. Kulkarni


Since, the first report on discovery of double helical structure of DNA by James Watson and Francis Crkk (April 1953, Nature), numerous papers have been published reporting function of non-coding RNAs (ncRNAs). On the basis of evidence and the expert’s opinion, it is well documented that majority of the human genome encodes RNAs that do not code for proteins. The aim of this communication is to summarize the importance of ncRNAs as regulators of several biological and developmental processes. Finally, this laconic review focuses on the approaches investigated for the delivery of ncRNAs.