Senescence lncRNAs govern cell surface components: lncRNA-OIS1 transcriptionally elevates DPP4

Rachel Munk, Kyoung Mi Kim, Myriam Gorospe, Kotb Abdelmohsen


With advancing age, senescent cells accumulate in tissues and organs, accelerating aging and age-related disease (e.g., diabetes, neurodegeneration, and cancers) (1). Cellular senescence is triggered by sublethal stresses including telomere shortening (replicative senescence), damage to DNA or other molecules (premature senescence), and oncogenic activation (oncogene-induced senescence, OIS) (2-5).