Article Abstract

Senescence lncRNAs govern cell surface components: lncRNA-OIS1 transcriptionally elevates DPP4

Authors: Rachel Munk, Kyoung Mi Kim, Myriam Gorospe, Kotb Abdelmohsen

Abstract

With advancing age, senescent cells accumulate in tissues and organs, accelerating aging and age-related disease (e.g., diabetes, neurodegeneration, and cancers) (1). Cellular senescence is triggered by sublethal stresses including telomere shortening (replicative senescence), damage to DNA or other molecules (premature senescence), and oncogenic activation (oncogene-induced senescence, OIS) (2-5).