Killing miR-softly: new clues to miRNA degradation by RNA targets

Francesco Nicassio


When talking about regulatory RNAs, and microRNAs in particular, attention should be paid to what types of molecules are present in the cell and in what numbers, rather than to their sizes. The distinction between small and long RNAs is based on RNA isolation protocols and is not a reflection of specific biogenesis pathways, regulatory mechanisms or biological roles. Conversely, sequence and quantity of expressed miRNAs are of paramount importance.