Long non-coding RNAs are driver to maintain the chromatin active regions at divergent transcriptional units

Understanding of the diverse role of the human long non-coding RNAs (lncRNAs) is a considerable emerging field in development and disease (1). LncRNAs are broadly defined as noncoding RNAs longer than 200 nucleotides, separating them from various classes of microRNAs (miRNAs), small nuclear RNAs (snRANs), and small nucleolar RNAs (snoRNAs) that function through distinct mechanisms (2,3). The majority of lncRNAs are transcribed by RNA polymerase II (RNAP2), hence sharing similarities with messenger RNAs (mRNAs).