Article Abstract

Long noncoding RNAs and their roles in skeletal muscle fate determination

Authors: Mackenzie Hagan, Mi Zhou, Muhammad Ashraf, Il-man Kim, Huabo Su, Neal L. Weintraub, Yaoliang Tang


Myogenic fate determination is important in skeletal muscle development, growth and repair. A variety of factors regulate myogenic cell determination via transcriptional and non-transcriptional mechanisms. Amongst these factors, long noncoding RNAs (lncRNAs) have gained considerable attention for their important roles in regulating myogenic differentiation and function. Many classes of lncRNAs have been discovered; various lncRNAs have been implicated in the regulation of myogenic cell fate determination and are the subject of this brief review.